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Meniscus Repair – Surgery for Cartilage Tears | We Care
Knee cartilage replacement therapy
Articular cartilage, most notably that which is found in the knee joint, is generally characterized by very low friction, high wear resistance, and poor regenerative qualities. It is responsible for much of the compressive resistance and load bearing qualities of the knee joint and, without it, walking is painful to impossible. Osteoarthritis is a common condition of cartilage failure that can lead to limited range of motion, bone damage and invariably, pain.
Due to a combination of acute stress and chronic fatigue, osteoarthritis directly manifests itself in a wearing away of the articulating surface and, in extreme cases, bone can be exposed in the joint. Some additional examples of cartilage failure mechanisms include cellular matrix linkage rupture, chondrocyte protein synthesis inhibition, and chondrocyte apoptosis. There are several different repair options available for cartilage damage or failure.
Non-surgical treatments
Osteoarthritis is the second leading cause of disability in the elderly population in the United States. It is a degenerative disorder that generally starts off relatively mild and escalates with time and wear. For those patients experiencing mild to moderate symptoms, the disorder can be dealt with by several non-surgical treatments.
The use of braces and drug therapies, such as anti-inflammatories (ex. diclofenac, ibuprofen, and naproxen), COX-2 selective inhibitors, hydrocortisone,have been shown to alleviate the pain caused by cartilage deficiency and some claim they may slow the degenerative process. The use of glucosamine and chondroitin has been shown to be a wholly ineffective treatment by recent studies in the U.S. and Europe.
Non-biological treatments
This type of repair, short of total joint replacement, can be divided into three groups. Treatments that remove the diseased and undermined cartilage with an aim to stop inflammation and pain include shaving (chondrectomy) and debridement. Another group of treatments consists of a range of abrasive procedures aimed at triggering cartilage production, such as drilling, microfracture surgery, chondroplasty, and spongialization. Laser assisted treatments, currently experimental, compose a third category; they combine the removal of diseased cartilage with cartilage reshaping and also induce cartilage proliferation.
It is interesting to note that debridement, introduced by Magnuson in 1941, does not have any scientific basis for existence; in fact, it is deleterious in terms of knee biomechanics. It is used palliatively as it temporarily relieves pain associated with arthritic inflammation. Many insurance companies (ex. Aetna) consider the procedure experimental because there is no evidence proving its effectiveness.
Abrasion, drilling, and microfracture originated 20 years ago. They rely on the phenomenon of spontaneous repair of the cartilage tissue following vascular injury to the subchondral bone.
Laser abrasion provides gentle cutting of the cartilage. It uses heat to induce alterations in the physical matrix, which results in shape change and stress reduction. Improving this therapy to make it more spatially selective would avoid excessive tissue damage such as air bubble formation, tissue necrosis, reactive synovitis, chondrolysis, and an acceleration of articular cartilage degeneration.
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Autologous chondrocyte implantation (ACI) and Carticel
Despite advances in materials science and innovations in knee repair, no current therapy can mimic the extraordinary biomechanical properties of cartilage. This notion drives initiatives in cell-based replacement technologies, such as autologous chondrocyte implantation (ACI). In the United States, Genzyme Corporation provides the only FDA approved ACI treatment, Carticel.
The Carticel treatment is designated for young, healthy patients with medium to large sized damage to cartilage. The procedure is not applicable to osteoarthritis patients.
During an initial procedure, the patient’s own chondrocytes are removed arthroscopically from a non load-bearing area from either the intercondylar notch or the superior ridge of the medial or lateral femoral chondyles. The 10,000 cells that are originally harvested are grown in vitro at Genzyme biosurgery for approximately six weeks until the population reaches 10-12 million cells.
After this cell proliferation period, the patient undergoes a second surgery in which the millions of chondrocytes are surgically injected into the patient. These cells are held in place by a periosteal flap, a small piece of soft tissue from the tibia, which is sutured over the damaged area to serve as a watertight lid. The implanted chondrocytes can then divide and integrate with surrounding tissue under the flap and potentially generate hyaline-like cartilage.
Though Carticel has not been studied as an effective procedure through a wide range of patient backgrounds, results suggest that some patients can return to pre-injury function. Over 10,000 procedures have been performed since Carticel was introduced in 1995, and approximately 1,500-3,000 are performed per year. The cost of the treatment ranges from $20,000-$35,000. CARTICEL II is the second generation of the CARTICEL procedure.
It is uses a “Fleece matrix” into which the grown harvested chondrocyte cells are planted. This fleece is then re-introduced back into the body usually via arthroscopy to begin the healing process. This CARTICEL II procedure is about to undergo clinical trials under the supervision of the FDA in the United States. This newer technique is known as matrix autologous chondrocyte implantation or (MACI). It is also available in Germany, UK, and Australia.
BioTissue Technologies GmbH [1] (Freiburg, Germany) has since moved the CARTICEL technology forward. A patients hyaline biopsy is taken, sent to their lab and grown into a 3D matrix of resorbable tissue. This matrix is then supplied back to the surgeon who then implants it back into the patient either via an open or arthroscopic procedure. It appears to be a lot simpler technique and resolves some of the issues of using Carticel under a periosteal patch. Other companies offering similar products include FAB (Fidia Advanced Biopolymers), Geistlich Biomaterials and Arthro Kinetics.
Autologous Mesenchymal Stem Cell Transplant
For years, the concept of harvesting stem cells and re-implanting them into one’s own body to regenerate organs and tissues has been embraced and researched in animal models. In particular, mesenchymal stem cells have been shown in animal models to regenerate cartilage[1]. Recently, there has been a published case report of successful cartilage growth in human knees using autologous mesenchymal stem cells.[2] An advantage to this approach is that a person’s own stem cells are used, avoiding transmission of genetic diseases. It is also minimally invasive, minimally painful and has a very short recovery period.
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